Analysis of the cannabidiol effects in epilepsy treatment based on seizure characteristics in EEG recordings – A review
Marta Kopanska 1, Danuta Ochojska 2, Julia Trojniak 3, Aleksandra Kawala-Sterniuk 4, Dariusz Mikolajewski 5 6, Waldemar Karwowski 7, Amir F Al-Bakri 8, Piotr Sterniuk 9, Jacek Szczygielski 10 11
- 1Department of Pathophysiology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.
- 2Department of Psychology, University of Rzeszow, Rzeszow, Poland.
- 3Student Science Club “Reh-Tech”, Institute of Medical Sciences, University of Rzeszow, Rzeszow, Poland.
- 4Department of Artificial Intelligence, Faculty of Information and Communication Technology, Wroclaw University of Science and Technology, Wroclaw, Poland.
- 5Faculty of Computer Science, Kazimierz Wielki University in Bydgoszcz, Bydgoszcz, Poland.
- 6Neuropsychological Research Unit, 2nd Clinic of the Psychiatry and Psychiatric Rehabilitation, Medical University in Lublin, Lublin, Poland.
- 7Computational Neuroergonomics Laboratory, Department of Industrial Engineering and Management Systems, University of Central Florida, Orlando, Florida, USA.
- 8Department of Biomedical Engineering, College of Engineering, University of Babylon, Babylon, Iraq.
- 9Institute of Law, University of Opole, Opole, Poland.
- 10Department of Neurosurgery, Institute of Medical Sciences, University of Rzeszow, Rzeszow, Poland.
- 11Department of Neurosurgery, Faculty of Medicine, Saarland University, Homburg, Germany.
Affiliationer
Epilepsy is a common neurological disorder with a significant burden on patients, and ~30% of cases are resistant to standard antiepileptic treatments. This has led to the exploration of alternative therapies, such as cannabidiol (CBD). Studies suggest that CBD may reduce the frequency and severity of seizures in patients with drug-resistant epilepsy. In addition to clinical monitoring, EEG is frequently used to assess brain function and monitor CBD’s effects on seizures, with documented improvements in EEG patterns among CBD-treated patients. Research indicates that CBD may decrease both the number and duration of seizures, observed clinically and in EEG manifestations. This narrative review summarizes current evidence on the efficacy of CBD in treating drug-resistant epilepsy and analyzes its mechanisms of action in various forms of treatment-resistant seizures and their EEG presentations.
Keywords: EEG; brain signals; cannabidiol; epilepsy.
