Cannabis Improves Clinical Outcomes and Quality of Life in Patients With Chronic Pouchitis
Timna Naftali 1 2, Lihi Bar-Lev Schleider 3, Hen Kayless 1 2, Zohar Bromberg 1, Iris Dotan 2 4, Efrat Broide 2 5
- 1Institute of Gastroenterology and Hepatology, Meir Medical Center, Kfar Saba, Israel.
- 2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
- 3Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel.
- 4Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
- 5Jecheskiel Sigi Gonczarowski Pediatric Gastroenterology Unit, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel.
Affiliationer
Many patients with ulcerative colitis after ileoanal pouch anastomosis report improvement of pouchitis with the use of cannabis. Nine patients with chronic pouchitis used 1 g/d of cannabis: 7 patients were male with average age 51 ± 16 years. Average partial pouchitis disease activity index were 11 (range 8-17), 6 (range 5-8), and 5 (range 4-8); endoscopic subscores were 7 .3 ± 2.3, 6 ± 1.1, and 4.4 ± 0.9; average bowel movements per day were 14 (range 8-20), 8 (range 2-13), and 10 (range 13-8); and quality of life increased from 72 ± 1 to 90 ± 16 and 97 ± 10 (P = 0.001) before cannabis treatment and after 8-12 and 52 weeks, respectively. No adverse events were reported.
Keywords: cannabis; ileoanal pouch anastomosis; pouchitis; quality of life; ulcerative colitis.
