International forskning

Epub 2023 Feb 15. Patient Reported Outcomes Using Medical Cannabis for Managing Pain in Charcot-Marie-Tooth Disease


Priscilla C Canals 1, Alexia G Aguilar 1, Gregory T Carter 2, C Miyabe Shields 3, Andrew Westerkamp 3, Meg D'Elia 4, Joy Aldrich 5, Robert N Moore 5, Allison T Moore 5, Brian J Piper 1 6

  • 1Department of Medical Education, Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
  • 2Providence St Luke’s Rehabilitation Medical Center, Hereditary Neuropathy Foundation Center of Excellence, Spokane, WA, USA.
  • 3Real Isolates LLC, Beverly, MA, USA.
  • 4CeresMed, South Burlington, VT, USA.
  • 5Hereditary Neuropathy Foundation, New York, NY, USA.
  • 6Center for Pharmacy Innovation and Outcomes, Precision Health Center, Forty Fort, PA, USA.

Affiliationer

Objective: Chronic pain is a major problem for patients with Charcot-Marie-Tooth (CMT) disease. This exploratory study examined patient reported efficacy of medical cannabis for pain management in this population. Methods: Participants (N = 56; 71.4% female; Age = 48.9, SD = 14.6; 48.5% CMT1) were recruited though the Hereditary Neuropathy Foundation. The online survey contained 52 multiple choice questions about demographics, medical cannabis use, symptomology, efficacy, and adverse effects. Results: Nearly all (90.9%) of respondents reported experiencing pain, including all (100%) females and 72.7% of males (chi-square P < .05) with 91.7% of respondents indicating cannabis provided at least 50% pain relief. The most frequent response was an 80% reduction in pain. Moreover, 80.0% of respondents reported using less opiates, 69% noted using less sleep medication, and 50.0% reported using less anxiety/antidepressant medications. Negative side effects were noted by 23.5% of respondents. However, almost all (91.7%) of that subgroup did not have plans to stop consuming cannabis. One-third (33.9%) possessed a medical cannabis certificate. Patient perceptions of their physicians' attitudes regarding patient medical cannabis use greatly impacted whether respondents informed their providers of their usage. Conclusion: The vast majority of patients with CMT reported that cannabis was effective to manage pain symptoms. These data support the need for prospective, randomized, controlled trials using standardized dosing protocols to further delineate and optimize the potential use of cannabis to treat pain related to CMT.

Keywords: Charcot Marie Tooth; cannabis; chronic pain; hereditary motor and sensory neuropathy; marijuana; neuropathic pain.